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Agency for Healthcare Research and Quality: Rockville, MD, 2008. A large outbreak of Clostridium difficile -associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe.

Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C.