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Gileads Advancing Access Program provides co-pay assistance for patients with insurance, though it is unavailable for those enrolled in government prescription drug programs like Medicare Part D, and a program also exists for patients without insurance who meet certain eligibility guidelines. The Patient Advocate Foundations Co-Pay Relief program offers additional assistance to eligible applicants.

Massachusetts has launched and California is launching a state drug assistance program. Some patients have taken to ordering generic forms of PrEP, approved by the FDA last year, over the internet. It additionally pointed to limited transportation options to PrEP providers in low-income and rural communities, healthcare providers being unable to offer sliding-scale services to low-income people, and departments of health lacking funds to launch HIV-prevention efforts.